Immunopathophysiology of pediatric CNS inflammatory demyelinating diseases
نویسندگان
چکیده
منابع مشابه
Therapeutic apheresis in pediatric patients with acute CNS inflammatory demyelinating disease.
BACKGROUND/AIMS In adults, plasma exchange (PE) has been shown to be an efficient treatment for severe relapses of acute inflammatory CNS demyelinating diseases. The aim of this study was to evaluate the safety and efficacy of this treatment in pediatric patients. METHODS We retrospectively analyzed a single-center cohort of pediatric patients with inflammatory CNS demyelinating disorders who...
متن کاملPediatric demyelinating diseases: multiple sclerosis or not?
tral nervous system demyelination have been increasingly recognized in children. Moreover, a much higher proportion of children (as compared to adults) suffer from a monophasic (and not chronic) demyelinating event such as acute disseminated encephalomyelitis or isolated optic neuritis, and transverse myelitis, often post-infectious. Differentiation between such acute monophasic illnesses and a...
متن کاملCerebrospinal fluid analysis in the context of CNS demyelinating diseases.
The central nervous system demyelinating diseases are a group of disorders with different etiologies, characterized by inflammatory lesions that are associated with loss of myelin and eventually axonal damage. In this group the most studied ones are multiple sclerosis (MS), neuromyelitis optic (NMO) and acute disseminated encephalomyelitis (ADEM). The cerebrospinal fluid is essential to differe...
متن کاملNeuromyelitis optica-IgG in childhood inflammatory demyelinating CNS disorders.
OBJECTIVE To determine seroprevalence of neuromyelitis optica (NMO)-IgG in childhood CNS inflammatory demyelinating disorders. METHODS We analyzed demographic, clinical, and radiologic data in a blinded fashion and assessed serum NMO-IgG status for 87 children: 41 with relapsing-remitting multiple sclerosis (RRMS), 17 with NMO, 13 with monophasic/recurrent optic neuritis (ON), 13 with transve...
متن کاملInflammatory demyelinating brain lesions heralding primary CNS lymphoma.
Brain biopsy plays a crucial role in the exploration of suspect white matter lesions in the differential diagnosis of primary central nervous system lymphoma (PCNSL) and inflammatory demyelination. We present the case of a previously healthy, immunocompetent woman, aged fifty-nine, who developed a histologically confirmed demyelinating white matter lesion months prior to the manifestation of a ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neurology
سال: 2016
ISSN: 0028-3878,1526-632X
DOI: 10.1212/wnl.0000000000002821